Postdoc in Cardiovascular Pathophysiology

Job beskrivelse

The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a position as Postdoc in the field of cardiovascular pathophysiology as per 1 November 2022 or as soon as possible thereafter. The position is a fixed-term full-time position for 2 years.

We offer a vibrant international research environment where English is the preferred language in the laboratory, at meetings and at seminars. The Department employs some 450 people and covers a range of research areas within Biomedicine. We contribute to the Bachelor’s degree programs in medicine, molecular medicine, odontology and the Master’s degree programs in biomedical engineering and medical chemistry. Our infrastructure is well developed with modern laboratories, core and animal facilities. You will work in the brand new ‘Skou Building’ as we are in the process of modernizing our old facilities. You can read more about the department here and about the faculty here.

About the research project

Tissue acidosis occurs in metabolic, respiratory, and cardiovascular disturbances. Whilst a decrease in pH is shared amongst these conditions, the metabolites accumulating parallel to H+ reflect the source of the acidosis. The accumulating metabolites were previously considered waste products or recognized as acid-base buffers and metabolic substrates, but it is now evident that several – e.g., lactate, ketone bodies, and bicarbonate – also act on specific cellular receptors.
Acidosis develops in the heart during increased pumping activity and as result of perfusion limitations. In the current project, we will evaluate the role of accumulating metabolites for hemodynamic control and cardiac inflammation and explore whether cellular metabolite receptors – on cardiomyocytes, the resistance vasculature, and immune cells – can be exploited for protection against ischemia and heart failure.
For these studies, you will be part of an enthusiastic team of interdisciplinary members studying human tissue samples and transgenic mouse models. We will induce ischemia in vitro (Langendorff) and in vivo, study development of cardiac infarcts and heart failure through cardiovascular phenotyping and histological staining, assess physical exercise capacity, and use flow cytometry and single-cell RNA sequencing to evaluate immune cell infiltration and transcriptomic adaptations.

Your job responsibilities

As Postdoc in cardiovascular pathophysiology your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance.

Your main tasks will consist of independent research of high international quality, including publication.

You will report to Professor Ebbe Boedtkjer.

Your competences

You have academic qualifications at PhD level, preferably within one or more of the following areas: cardiovascular physiology, molecular biology, transport physiology. Experience with and license for animal experiments are desired. Training will be given to ensure a quick learning curve for techniques not currently mastered by the candidate.

As a person, you are ambitious, flexible, and highly motivated; you take ownership and possess good communication and interpersonal skills.We expect you to be fluent in oral and written English.

For the driven candidate, this project based on strong synergies between local research environments will create excellent possibilities for personal and scientific development.

In order to be assessed as qualified for a Postdoc position, you must meet these academic criteria.

Shortlisting will be used.

Questions about the position

If you have any questions about the position, please contact Professor Ebbe Boedtkjer tel.: (+45) 24870240, mail: eb@biomed.au.dk.

Your place of work will be the Department of Biomedicine, Hoegh-Guldbergs Gade 10, DK-8000 Aarhus C, Denmark.

We expect to conduct interviews in September.

Terms of employment

• Appointment as a postdoc requires academic qualifications at PhD level.
• Further information on the appointment procedure can be found in the Ministerial Order on the Appointment of Academic Staff at Universities.
• The appointment is in accordance with the Danish Confederation of Professional Associations (Akademikerne).
• Remuneration is in accordance with the above, and the Salary agreement catalogue for staff at Health.
• The yearly base salary for a fulltime postdoc is between DKK 473.733,12 and DKK 527.059,29 depending on the years of working experience after achieved MSc degree. The base salary includes a position related supplement and pension (17.1 %). Additional supplement(s) for special qualifications can be negotiated. Authorisation supplemement(s) will be granted, if relevant for the position. Your local eligible trade union representative at Aarhus University negotiates your salary on your behalf.
• Researchers recruited from abroad are offered a special researcher tax scheme with a lower tax rate.
• Further information on qualification requirements and job description can be found in the Ministerial Order on Job Structure for Academic Staff

Application

Your application must include the following:

• Motivated application
• Curriculum Vitae
• Diploma
• Template for applicant – postdoc
• A list of publications
• A teaching portfolio. We refer to Guideline on the use of teaching portfolios
• A maximum of five of the publications of greatest relevance to the job may be submitted (optional)
• Strategic research plan can be uploaded (optional)
• Coauthor statement(s) can be uploaded (optional)
• References/recommendations can be uploaded separately in the e-recruitment system (optional)

We refer to the faculty’s Guidelines for applicants.

The assessment committee may decide to include non-submitted material in its statement. In such cases, you will be informed and obliged to submit material, unless your application is withdrawn.

Aarhus University’s ambition is to be an attractive and inspiring workplace for all and to foster a culture in which each individual has opportunities to thrive, achieve and develop. We view equality and diversity as assets, and we welcome all applicants.

Letter of reference

If you want a referee to upload a letter of reference on your behalf, please state the referee’s contact information when you submit your application. We strongly recommend that you make an agreement with the person in question before you enter the referee’s contact information, and that you ensure that the referee has enough time to write the letter of reference before the application deadline.
Unfortunately, it is not possible to ensure that letters of reference received after the application deadline will be taken into consideration.

International applicant?

Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please find more information about entering and working in Denmark here. Aarhus University also has a Junior Researcher Development Programme. You can read more about it here.

The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University’s website.
Aarhus University
Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 38,000 students (FTEs) and 8,000 employees, and has an annual revenues of EUR 885 million. Learn more at www.international.au.dk/

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